Prognosis in Disseminated Sclerosis

Eye Changes in Disseminated Sclerosis

What is probably the first written account of the clinical features of disseminated sclerosis is contained in the diary of Augustus D'Este, the illegitimate son of Prince Augustus Frederick, and grandson of George III. The first manifestations of the disease in his case, as m some 30% of all such patients, were referable to the eyes. In 1822, we read, he journeyed to visit a much-loved relative...

Prevalence of Disseminated Sclerosis

CHARCOT remarked in 1868: "Even today I do not believe that disseminated sclerosis is known in England," and this may have been true, although Moxon described a case in 1873 and others some years later. Williamson (1903) reported a proportion of patients with disseminated sclerosis equivalent to 27 cases for every 1,000 nervous diseases seen at the Manchester Royal Infirmary over a period of 10...

Familial Incidence of Disseminated Sclerosis

IN Northern Ireland we have recently completed a survey of disseminated sclerosis; 700 cases have been traced and examined and in 44 families we have found more than one member affected, giving a familial incidence of 6.58 per cent.; this figure corresponds closely with the incidence in recent surveys from the Middlesex Hospital 6.5 per cent. (Pratt, et al., 1951), and from the Bristol area 6 p...

Tuberous Sclerosis with Disseminated Malignancy.

Tuberous sclerosis is characterized by typical skin and clinical manifestations with predilection to neoplasia. We describe the case of a 42-year old female who presented with a mass and pain in right lumbar region with constitutional symptoms and generalized body aches since last one year. She had adenoma sebaceum, subungual fibromas and hepatomegaly. CT chest, abdomen and MRI revealed mass in...

Veterinary Workers and Disseminated Sclerosis.